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3D Statistical Parametric Mapping of quiet sleep EEG in the first year of life

Filed under:

Pedro A. Valdes-Sosa (Cuban Neuroscience Center), Jorge Bosch-Bayard (Cuban Neurosceince Center)

This work extends previously developed 3D SPM for Electrophysiological Source Imaging (Bosch et al., 2001) for neonate EEG. It builds on a prior paper by our group that established age dependent means and standard deviations for the scalp EEG Broad Band Spectral Parameters of children in the first year of life. We now present developmental equations for the narrow band log spectral power of EEG sources, obtained from a sample of 93 normal neonates from age 1 to 10months in quiet sleep. The main finding from these regressions is that EEG power from 0.78 to 7.5Hz decreases with age and also for 45-50Hz. By contrast, there is an increase with age in the frequency band of 19-32Hz localized to parietal, temporal and occipital areas. Deviations from the norm were analyzed for normal neonates and 17 with brain damage. The diagnostic accuracy (measured by the area under the ROC curve) of EEG source SPM is 0.80, 0.69 for average reference scalp EEG SPM, and 0.48 for Laplacian EEG SPM. This superior performance of 3D SPM over scalp qEEG suggests that it might be a promising approach for the evaluation of brain damage in the first year of life.

Hernandez-Gonzalez, G., Bringas-Vega, M. L., Galan-García, L., Bosch-bayard, J., Melie-garcia, Y. L.-ceballos L., Valdes-Urrutia, L., Cobas-Ruiz, M., et al. (2011). Multimodal Quantitative Neuroimaging Databases and Methods: the Cuban Human Brain Mapping Project. Clinical Eeg and Neuroscience, 42(3), 1-11.

Bosch-Bayard, J., Valdés-Sosa, P. a, Fernandez, T., Otero, G., Rivero, B. P., Ricardo-Garcell, J., González-Frankenberger, B., et al. (2011). 3D Statistical Parametric Mapping of quiet sleep EEG in the first year of life. NeuroImage.

3D Statistical Parametric Mapping of quiet sleep EEG in the first year of life
MIP of Z-scores in the delta band for both normal and pathological neonates.Maximum Intensity Projection (MIP), top view, of the Z-scores for the 17 pathological neonates (top of the figure, demarked by black lines) and the 93 normal subjects at the frequency (in the Delta band)most deviant from the norm. Z-scores for normal subject swere obtained by recalculating the norms each time using the leave one out procedure. All Z-scores were thresholded to a common value of±2.4 SD. Two of the pathological cases only showed Z-scores above the threshold in the Beta band between 15 and 24 Hz and appear in white in this figure. The third one was included as pathological due to clinical evidence of brain damage, but with visual EEG inside normal range. This case did not show Z-scores beyond the limits in any frequency of the whole frequency range.
Preferred presentation format: Poster
Topic: Neuroimaging

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